Comparative proteomics and structure-based approach to unravel the therapeutic drug target of Theileria species.

ABSTRACT: Theileriosis, caused by protozoan parasites of genus Theileria, primarily affects both domestic and wild ruminants. It can lead to significant economic losses in livestock farming due to decreased productivity and high mortality rates in susceptible animals, while treatment measures are not cost-effective. Since most of mechanisms of this disease remain unknown, this study investigates the differences in the mode of pathogenesis between transforming and non-transforming groups through an in silico comparative proteomics approach to recognize the key players involved in host cell transformation. Although the major biological processes and molecular functions are almost conserved between the two groups, PEST-motif containing secretory proteins of SfiI, SVSP, and Tash-AT gene families were id

SUBMITTER: Majumder A 

PROVIDER: S-EPMC12008689 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature