Persistent postremission clonal hematopoiesis shapes the relapse trajectories of acute myeloid leukemia.

ABSTRACT:

Abstract

Mutations found in acute myeloid leukemia (AML) such as DNMT3A, TET2, and ASXL1 can be found in the peripheral blood of healthy adults, a phenomenon termed clonal hematopoiesis (CH). These mutations are thought to represent the earliest genetic events in the evolution of AML. Genomic studies on samples acquired at diagnosis, remission, and at relapse have demonstrated significant stability of CH mutations after induction chemotherapy. Meanwhile, later mutations in genes such as NPM1 and FLT3 have been shown to contract at remission, and in the case of FLT3 often are absent at relapse. We sought to understand how early CH mutations influence subsequent evolutionary trajectories throughout remission and relapse in response to induction chemotherapy. We assembled a retrospect

SUBMITTER: Chow RD 

PROVIDER: S-EPMC12008691 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature