Cross-ancestry analyses of Chinese and European populations reveal insights into the genetic architecture and disease implication of metabolites.

ABSTRACT: Differential susceptibilities to various diseases and corresponding metabolite variations have been documented across diverse ethnic populations, but the genetic determinants of these disparities remain unclear. Here, we performed large-scale genome-wide association studies of 171 directly quantifiable metabolites from a nuclear magnetic resonance-based metabolomics platform in 10,792 Han Chinese individuals. We identified 15 variant-metabolite associations, eight of which were successfully replicated in an independent Chinese population (n = 4,480). By cross-ancestry meta-analysis integrating 213,397 European individuals from the UK Biobank, we identified 228 additional variant-metabolite associations and improved fine-mapping precision. Moreover, two-sample Mendelian randomization analys

SUBMITTER: Lin C 

PROVIDER: S-EPMC12008806 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature