Metacp: a versatile software package for combining dependent or independent p-values.

ABSTRACT:

Background

We present metacp an open-source software package which implements an abundance of statistical methods for the combination of both independent p-values, with methods such as Fisher's, Stouffer's and Edgington's, and dependent p-values, with methods such as Brown's method and the Cauchy Combination Test.

Results

The tool is available in Python and STATA, it is very fast, and it is easy to use, requiring only minimal input. It offers a useful resource for combining both independent and dependent p-values, responding to diverse analytical needs for practitioners performing meta-analyses and bioinformaticians developing tools for a variety of applications. Depending on the input data it can be used for gene-based testing, for analysis of multiple traits in GWAS, or fo

SUBMITTER: Nikolitsa EK 

PROVIDER: S-EPMC12008841 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature