Increased level of serum asymmetric dimethylarginine in individuals with more severe cognitive impairment, as evaluated using Montreal Cognitive Assessment instead of Mini-Mental State Examination.

ABSTRACT:

Background

This study aimed to explore the link between cognitive impairment and levels of asymmetric dimethylarginine (ADMA).

Methods

The study included 172 patients from the Department of Geriatrics and Neurology at the Second Affiliated Hospital of Harbin Medical University. The enrollment period spanned from October 2013 to July 2014. To assess their cognitive function, we used the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA). Additionally, automatic biochemical analyzers were employed to measure various biochemical blood indexes, while enzyme-linked immunosorbent assay was used to determine the serum ADMA concentrations.

Results

The participants were categorized into four groups based on the MMSE scale, which reflects cognitio

SUBMITTER: Liu L 

PROVIDER: S-EPMC12008880 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature