Calycosin ameliorates albuminuria in nephrotic syndrome by targeting Notch1/Snail pathway.

ABSTRACT:

Background

Heavy proteinuria is an important hallmark for kidney disease including nephrotic syndrome. Astragali Radix, a traditional Chinese herb, holds the potential to alleviate nephrotic syndrome; however, the underlying mechanism has not been completely clarified. The study aimed to explore the role of calycosin (C₁₆H₁₂O₅), a major active component of Astragali Radix, in regulating adriamycin-induced proteinuria.

Methods

A rat model of nephrotic syndrome was established through two adriamycin injections within two weeks (4 mg/kg for the first week and 2 mg/kg for the second week). After the induction of renal injury, 10 mg/kg or 20 mg/kg calycosin was intraperitoneally injected into rats for four weeks. Before euthanasia of rats, urine a

SUBMITTER: Ma X 

PROVIDER: S-EPMC12008911 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature