Novel insights into immune-gut microbiota interactions in colorectal cancer: a Mendelian randomization study.

ABSTRACT:

Background

The relationship between immune cells and colorectal cancer (CRC) development has been extensively studied; however, the mediating role of gut microbiota in this relationship remains poorly understood.

Methods

We utilized summary data from genome-wide association studies (GWAS) to analyze 731 immune cell phenotypes, 473 gut microbiota, and CRC-related data. A two-step mediation analysis was employed to identify mediating gut microbiota. The primary analysis method was inverse variance weighting (IVW), supplemented by MR-Egger, simple mode, weighted median, and weighted mode analyses. Robustness of the results was ensured through systematic sensitivity analyses.

Results

Our analysis identified 13 immune cell phenotypes significantly associated with CRC, incl

SUBMITTER: Liu Z 

PROVIDER: S-EPMC12008918 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature