Development of the G-Risk scoring system utilizing inflammatory and tumor biomarkers to improve prognostic accuracy in gastric cancer patients without lymphovascular invasion.

ABSTRACT:

Objective

This study aimed to establish the G-Risk scoring system, a prognostic model based on inflammatory and tumor biomarkers, to enhance survival predictions for gastric cancer patients without lymphovascular invasion (LVI) and guide more tailored treatment strategies.

Methods

The key biomarkers associated with survival outcomes were identified using univariate and multivariate Cox regression analyses. These biomarkers were selected from a range of inflammatory and tumor markers to construct the G-Risk scoring system, which was specifically developed to improve prognostic accuracy in patients without LVI.

Results

The G-Risk score effectively stratified patients into high-risk and low-risk groups, achieving an AUC of 0.660, demonstrating strong predictive performan

SUBMITTER: Liu E 

PROVIDER: S-EPMC12008984 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature