Circular RNAs in endometriosis analyzed through RNA sequencing and bioinformatics for expression profile.

ABSTRACT:

Background

Endometriosis severely affects women's physical and mental health; it is particularly important to find targets for the treatment and diagnosis of endometriosis.

Method

This research aimed to investigate the circRNA expression pattern in endometriosis, a type of non-coding RNA that can modulate parental gene expression by acting as miRNA sponges. Through high-throughput sequencing, we analyzed the circRNA expression profile in endometriosis patients in comparison to individuals without the condition.

Results

We detected 371 circular RNAs (circRNAs) showing increased expression and 308 circRNAs displaying decreased expression levels. To validate these findings, we employed quantitative real-time PCR (qRT-PCR) to confirm the expression of the top three differ

SUBMITTER: Yue Y 

PROVIDER: S-EPMC12009022 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature