Nanopore Stochastic Sensing Based on Non-covalent Interactions.

ABSTRACT: A variety of species could be detected by using nanopores engineered with various recognition sites based upon non-covalent interactions, including electrostatic, aromatic, and hydrophobic interactions. The existence of these engineered non-covalent bonding sites was supported by the single-channel recording technique. The advantage of the non-covalent interaction-based sensing strategy was that the recognition site of the engineered nanopore was not specific for a particular molecule but instead selective for a class of species (e.g., cationic, anionic, aromatic, and hydrophobic). Since different species produce current modulations with quite different signatures represented by amplitude, residence time, and even characteristic voltage-dependence curve, the non-covalent interaction-based

SUBMITTER: Chen X 

PROVIDER: S-EPMC12009080 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature