Heterotelechelic Organometallic PEG Reagents Enable Modular Access to Complex Bioconjugates.

ABSTRACT: Organometallic oxidative addition complexes (OACs) have recently emerged as a powerful class of reagents for the rapid and chemoselective modification of biomolecules. Notably, the steric and electronic properties of the ligand and aryl group can be modified to tune the kinetic profile of the reaction and permit regioselective S-arylation. Using the recently developed dicyclohexylphosphine-based bidentate P,N-ligated Au(III) OACs, we computationally and experimentally examined the effects of sterically bulky and electron deficient aryl substrates to achieve selective S-arylation. With this mechanistic insight, aryl substrates based on 4-iodoanisole and 3,5-dimethyl-4-iodoanisole were incorporated as end groups to generate a heterotelechelic bis-Au(III) poly(ethy

SUBMITTER: Kunkel GE 

PROVIDER: S-EPMC12009180 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature