TROAP promotes esophageal squamous cell carcinoma progression via the PI3K/AKT pathway.

ABSTRACT:

Purpose

Trophinin-associated protein (TROAP) plays a crucial role in various human cancers. However, its involvement in esophageal squamous cell carcinoma (ESCC) remains unclear. This study aimed to explore the clinical significance and biological function of TROAP in ESCC.

Methods

The expression and clinical relevance of TROAP in ESCC were analyze using GEO and TCGA databases. TROAP expression in ESCC samples was further validated by qRT-PCR, western blotting, and immunohistochemistry. In vitro and in vivo experiments were performed to assess TROAP's role in ESCC progression. RNA-seq analysis followed by western blotting and pathway-specific activator were conducted to explore the underlying mechanism.

Results

TROAP was found to be overexpressed in ESCC and was posit

SUBMITTER: Shi L 

PROVIDER: S-EPMC12009240 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature