ITGA5 induces mesenchymal transformation to promote gliomas progression via PI3K/AKT/mTORC1 signaling pathway.

ABSTRACT: Glioma is a common malignant tumor of the central nervous system, characterized by high malignancy, strong invasiveness and high recurrence rate. Integrin α5 (ITGA5), a member of the integrin adhesion molecule family, has been reported to be associated with tumor progression and metastasis. In this study, we first identified the overexpression of ITGA5 in glioma through bioinformatics analysis. Kaplan-Meier analysis, Cox regression analysis, and nomogram modeling revealed that high ITGA5 expression was significantly associated with poor prognosis in glioma patients. The ssGSEA showed that the high expression of ITGA5 had a higher level of immune cell infiltration, especially aDCs, B cells, CD8 + T cells, Macrophages, T helper cells, etc. To validate the results of bioinformatics analysis,

SUBMITTER: Zhang M 

PROVIDER: S-EPMC12009355 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature