RNF128 promotes gastric cancer progression by inhibiting autophagy-dependent ferroptosis through Beclin1 ubiquitination.

ABSTRACT: As an important protein post-translational modification process, ubiquitination plays an indispensable role in the regulation of gastric cancer (GC) occurrence and development. And recent studies have demonstrated that this modification is closely related to regulated cell death. This suggests that our therapeutic approach to inhibit the malignant progression of GC by regulating the intracellular death mode through ubiquitination modification becomes possible. Although ubiquitination modification has been well described in some tumorigenesis, its potential role and specific mechanisms are still unknown. In the present study, we identified RNF128, an E3 ubiquitin ligase with a RING structural domain, whose expression was significantly increased in GC. In-depth studies showed that knockdown

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC12009371 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature