The role of adherent-to-suspension transition factors in clear cell renal cell carcinoma progression: a comprehensive analysis.

ABSTRACT: Recent studies have identified a biological process called adherent-to-suspension transition (AST) as a key factor in promoting metastasis. The involvement of AST in the progression of clear cell renal cell carcinoma (ccRCC) remains largely unexplored. We comprehensively investigated the overall landscape of all 20 AST factors at the pan-cancer level. The risk stratification method and the prognostic model based on AST factors were established with consensus clustering analysis and LASSO regression algorithm. The potential molecular mechanism of AST was further investigated by multi-omics analysis and cell experiments. We found that AST factors play distinct roles in different cancer types. Consequently, we utilized AST factors to develop a risk stratification method and a prognostic model

SUBMITTER: Xu C 

PROVIDER: S-EPMC12009395 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature