Determinants of retinopathy and short-term neurological outcomes after cerebral malaria.

ABSTRACT: Neurological abnormalities are frequent after cerebral malaria (CM) resolves. The identification of survivors that should be prioritized during follow-up after CM is necessary for post-hospitalization care. We analysed social, clinical, and immune determinants of malarial retinopathy (MR) and short-term neurological outcomes after CM. Children aged 24 to 71 months with CM were prospectively followed-up until 28 days after admission at two hospitals in Benin. Direct ophthalmoscopy was performed shortly after admission. Plasma biomarkers were measured at admission. A neurocognitive deficit screener was administered at discharge and 21-28 days after admission. Of 70 children, 20 died before discharge (28.6%). Neurological deficits decreased from 100% on admission to 48.9% at discharge, and to

SUBMITTER: Bodeau-Livinec F 

PROVIDER: S-EPMC12009428 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature