Effect of long-term treatment with memantine on mortality in patients with major cognitive disorders: A systematic review and meta-analysis.

ABSTRACT:

Background

Dementia is responsible for a reduction in life expectancy, and the effect of memantine on mortality is still poorly understood. Our aim was to evaluate the effect of long-term treatment with memantine on all-cause mortality.

Methods

In this systematic review and meta-analysis, we searched five databases from their creation to June 2024.

Results

We found 12 randomized trials (n = 4266) and 7 observational studies (n = 20,216). Treatment with memantine was associated with a reduction in all-cause mortality (risk ratios [RRs] 0.81, 95% CI: 0.72-0.92, p = 0.001). In the sensitivity analysis, the pooled RR was similar for randomized controlled trials (RCT) (RR 0.86) and non-randomized studies (RR 0.81) but pooled results from RCTs did not r

SUBMITTER: Zolnowski-Kolp V 

PROVIDER: S-EPMC12009441 | biostudies-literature | 2025 Apr-Jun

REPOSITORIES: biostudies-literature