Neuropeptide inactivation regulates egg-laying behavior to influence reproductive health in Caenorhabditis elegans.

ABSTRACT: Neural communication requires both fast-acting neurotransmitters and neuromodulators that function on slower timescales to communicate. Endogenous bioactive peptides, often called "neuropeptides," comprise the largest and most diverse class of neuromodulators that mediate crosstalk between the brain and peripheral tissues to regulate physiology and behaviors conserved across the animal kingdom. Neuropeptide signaling can be terminated through receptor binding and internalization or degradation by extracellular enzymes called neuropeptidases. Inactivation by neuropeptidases can shape the dynamics of signaling in vivo by specifying both the duration of signaling and the anatomic path neuropeptides can travel before they are degraded. For most neuropeptides, the identity of the relevant inact

SUBMITTER: Lo JY 

PROVIDER: S-EPMC12009563 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature