Bivariate genome-wide association study of circulating fibrinogen and C-reactive protein levels.

ABSTRACT:

Background

Fibrinogen and C-reactive protein (CRP) play an important role in inflammatory pathways and share multiple genetic loci reported in previously published genome-wide association studies (GWAS), highlighting their common genetic background. Leveraging the shared biology may identify further loci pleiotropically associated with both fibrinogen and CRP.

Objectives

To identify novel genetic variants that are pleiotropic and associated with both fibrinogen and CRP, by integrating both phenotypes in a bivariate GWAS by using a multitrait GWAS.

Methods

We performed a bivariate GWAS to identify further pleiotropic genetic loci, using summary statistics of previously published GWAS on fibrinogen (n = 120 246) from the Cohorts for Heart and Aging Research in Genomic E

SUBMITTER: Hahn J 

PROVIDER: S-EPMC12009655 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature