Drug-induced liver injury (DILI) ascribed to non-steroidal anti-inflammatory drugs (NSAIDs) in the USA-Update with genetic correlations.

ABSTRACT:

Objective

To describe patients with NSAID-DILI, including genetic factors associated with idiosyncratic DILI.

Methods

In DILIN, subjects with presumed DILI are enrolled and followed for at least 6 months. Causality is adjudicated by a Delphic approach. HLA sequencing of multiethnic NSAID-DILI patients and HLA allele imputation of matching population controls were performed following overall, class and drug-based association analysis. Significant results were tested in a non-Hispanic White (NHW) case-control replication cohort.

Results

Between September 2004 and March 2022, causality was adjudicated in 2498, and 55 (41 [75%] women) were assessed as likely due to NSAIDs. Median age at onset was 55 y (range 22-83 y). Diclofenac was the causative drug in 29, celecoxib in

SUBMITTER: Bonkovsky HL 

PROVIDER: S-EPMC12009671 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature