Fig Meal Replacement Powder Ameliorates Obesity, Oxidative Stress and Intestinal Microbiota in Mice Fed With High-Fat Diet.

ABSTRACT: Figs, known for their high-antioxidant capacity, have shown potential in regulating obesity. However, research on fig-based products and the mechanisms behind their effects remains limited. This study aims to systematically evaluate the potential of fig meal replacement powder (FMRP) in regulating obesity and mitigating obesity-induced oxidative stress through both in vitro and in vivo experiments, while also elucidating its underlying mechanisms. The results demonstrated that FMRP exhibited superior nutritional value and antioxidant activity compared to commercially available alternatives. Furthermore, FMRP significantly reduced weight gain, improved lipid metabolism, alleviated liver damage and oxidative stress, and positively modulated the gut microbiota in high-fat diet (HFD)-fed mice.

SUBMITTER: Xu M 

PROVIDER: S-EPMC12009752 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature