SHP099-containing multi-targeting hydrogel promotes rapid skin reconstruction through modulating a variety of cells.

ABSTRACT:

Introduction

Adult wound scarring result in functional skin deficits. However, the development of effective measures to modulate the entire wound healing to encourage the skin function reconstruction is still a clinical challenge, as multiple cells are involved in wound healing hierarchically. Hydrogel scaffolds with long-lasting local release provide new insights into the clinical relevance of entire wound healing.

Methods

Herein, a multi-targeting hydrogel loaded with SHP099 (Gel-SHP) is designed to modulate multiple cells during wound repair.

Results

Our results show that Gel-SHP promotes rapid reconstruction of wound skin by modulating macrophages in the inflammatory stage, fibroblasts in the regeneration stage and smooth muscle cells in the remodelling stage. Gel

SUBMITTER: Liu Z 

PROVIDER: S-EPMC12009829 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature