Evaluating the role of astragalus polysaccharide in modulating immune infiltration and enhancing prognostic biomarkers in pediatric acute myeloid leukemia.

ABSTRACT:

Background

Childhood acute myeloid leukemia (AML) constitutes a significant proportion of pediatric malignancies, with current treatment options remaining limited. This study aimed to investigate the role of Astragalus polysaccharide (APS) in immune infiltration and prognosis of pediatric AML.

Methods

Differentially expressed genes (DEGs) were identified from the GEO database (dataset GSE2191), and APS-related genes (APSRGs) were obtained from the Swiss Target Prediction platform. DEGs with |logFC| > 1 and p < 0.05 were intersected with APSRGs to identify APS-related differentially expressed genes (APSRDEGs), visualized using a Venn diagram. A protein-protein interaction (PPI) network analysis was conducted to identify hub genes. Gene Ontology (GO) and KEGG enrichment analys

SUBMITTER: He MH 

PROVIDER: S-EPMC12009888 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature