<i>LILR</i> genotype imputation with attribute bagging (LIBAG): leukocyte immunoglobulin-like receptor copy number imputation system.

ABSTRACT: There are ten leukocyte immunoglobulin (Ig)-like receptor (LILR) genes, i.e., five genes encoding activating receptors (LILRA1, LILRA2, LILRA4, LILRA5, and LILRA6) characterized by their truncated cytoplasmic tails, and five genes encoding inhibitory receptors (LILRB1, LILRB2, LILRB3, LILRB4, and LILRB5) characterized by their extended cytoplasmic tails containing immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Among these, LILRB3, LILRA6, and LILRA3 are known for harboring high frequencies of copy number variations (CNVs). However, the presence of CNVs in the leukocyte receptor complex (LRC) region complicates single nucleotide polymorphism (SNP) association analysis within commercially available SNP microarray datasets. Thi

SUBMITTER: Khor SS 

PROVIDER: S-EPMC12009894 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature