CD147 regulates the Rap1 signaling pathway to promote proliferation, migration, and invasion, and inhibit apoptosis in colorectal cancer cells.

ABSTRACT: The malignant progression of colorectal cancer (CRC) is intimately associated with the abnormal regulation of transmembrane glycoprotein CD147. However, the molecular mechanism via the Rap1/Rap1GAP signaling axis has not been elucidated. This study, through integrated bioinformatics analysis, discovered that the expression of CD147 in CRC tissues was significantly higher than that in adjacent tissues, and patients with high expression had a shorter overall survival. Immunohistochemistry and Western blot confirmed that the expression level of CD147 protein in CRC tissues was higher than that in adjacent tissues. Moreover, qRT-PCR verified a positive correlation between the expressions of CD147 and Rap1. Immunofluorescence clearly indicated that CD147 was specifically enriched in the cell me

SUBMITTER: Xiaoxia F 

PROVIDER: S-EPMC12009992 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature