Retinoid-impregnated nanoparticles enable control of bone growth by site-specific modulation of endochondral ossification in mice.

ABSTRACT: Growth-plate (GP) injures in limbs and other sites can impair GP function and cause deceleration of bone growth, leading to progressive bone lengthening imbalance, deformities and/or physical discomfort, decreased motion and pain. At present, surgical interventions are the only means available to correct these conditions by suppressing the GP activity in the unaffected limb and/or other bones in the ipsilateral region. Here, we aimed to develop a pharmacologic treatment of GP growth imbalance that involves local application of nanoparticles (NP)-based controlled release of a selective retinoic acid nuclear receptor gamma (RARγ) agonist drug. When RARγ agonist-loaded NP were implanted near the medial and lateral sides of proximal tibial growth plate in juvenile C57BL/6J mice, the GP underwe

SUBMITTER: Matsuoka M 

PROVIDER: S-EPMC12010157 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature