Pregnancy-specific glycoproteins as potential drug targets for female lung adenocarcinoma patients.

ABSTRACT: Recently, the mRNA presence of pregnancy-specific glycoproteins (PSGs) in cancer biopsies has been shown to be associated with poor survival. Given the pregnancy-related function of PSGs, we hypothesized that PSGs might act in a sex-dependent behavior in cancer patients. A differential sex effect of PSG genes with respect to tumor immune landscape and cancer outcomes was investigated using statistical, bioinformatic, and machine learning analyses in The Cancer Genome Atlas (TCGA) data. The resulting findings were then validated in the Clinical Proteomic Tumor Analysis Consortium (CPTAC) data. In a pan-cancer TCGA data analysis, the strongest PSG-related sex difference for the prognostic association was found in lung adenocarcinoma (LUAD). Kaplan-Meier analysis revealed that expression of P

SUBMITTER: Oh JH 

PROVIDER: S-EPMC12010166 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature