Change in Structural Connectivity Following Stereotactic Thermocoagulation in Mesial Temporal Lobe Epilepsy Patients.

ABSTRACT:

Aims

To examine the association between postoperative lesions in distinct ROIs of the brain and the impact that their ablation would have on the structural and functional brain connectivity relative to outcomes.

Methods

We retrospectively reviewed 21 patients with refractory unilateral MTLE. The percentage of each ablated gray matter region of interest (ROIs) was calculated, using a voxel-by-voxel comparison. The percentage of the affected fibers was calculated by assessing the neuronal change reflected by a decrease in anisotropy in the repeat scans (i.e., pre and postoperative). Graph theory analysis was used to investigate the change in the pre and postoperative structural and functional networks between the seizure-free and non-seizure-free groups.

Results

Fifteen

SUBMITTER: Jean S 

PROVIDER: S-EPMC12010210 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature