Faecal microbiota transplantation in Crohn's disease: an Australian randomised placebo-controlled trial protocol.

ABSTRACT:

Introduction

The enteric microbiota drives inflammation in Crohn's disease. Yet, there are no placebo controlled trials evaluating the efficacy and safety of faecal microbiota transplantation (FMT) in inducing and maintaining remission in patients with active Crohn's disease. The Microbial Restoration (MIRO) study aims to establish this evidence.

Methods and analysis

At two specialist inflammatory bowel disease centres, 120 enrolled patients will have a 3-week period of diet optimisation (removal of ultra-processed foods) together with a 7-day course of antibiotics (to facilitate subsequent FMT engraftment). Patients will then be stratified to upper gut (for disease proximal to the splenic flexure) or lower gut (distal to the splenic flexure) disease. Patients will then be r

SUBMITTER: Fehily SR 

PROVIDER: S-EPMC12010309 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature