Proton pump inhibitors and the risk of gastric cancer: a systematic review, evidence synthesis and life course epidemiology perspective.

ABSTRACT:

Objectives

Since proton pump inhibitors (PPI) have been introduced, many concerns were raised regarding potential gastric carcinogenicity. We aim to summarise and weigh the epidemiological evidence and address possible causality.

Design

Systematic literature review, evidence synthesis and life-course assessment.

Data sources

PubMed, Web of Science and Cochrane database (from inception up to October 2024), and back- and forward citation tracking (Web of Science).

Eligibility criteria

Original studies and quantitative evidence syntheses assessing the association between PPIs and gastric cancer in humans, without language restrictions.

Data extraction and synthesis

Study design, definitions (and participant numbers) of PPI use and gastric cancer, study char

SUBMITTER: Brusselaers N 

PROVIDER: S-EPMC12010335 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature