A novel risk stratification system for primary small-cell carcinoma of the esophagus: indication for prognostication and staging.

ABSTRACT:

Background

Primary small cell carcinoma of the oesophagus (PSCCE) is a gastrointestinal tumour of rare onset. The current study was to investigate the role of a novel risk stratification system (RSS) for PSCCE.

Methods

The study included patients with PSCCE attending any of five medical institutions in China in 2008-2021, four of which served as a training set (n = 422) for construction of the RSS while the other served as a separate cohort (n = 256) for validation of the model. The RSS was established based on covariates associated with overall survival (OS) with a two-sided P-value of < 0.05 in multivariable regression. Survival discrimination of RSS was assessed.

Results

In the training cohort, multivariate regression analysis revealed age, Eastern Cooperati

SUBMITTER: Yang Y 

PROVIDER: S-EPMC12010368 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature