The global progress and quality assessment of research on the association between circulating tumor DNA and clinical prognosis: a systematic review.

ABSTRACT:

Objective

Circulating tumor DNA (ctDNA) has shown potential as a prognostic biomarker in patients with solid tumors. This study aimed to systematically summarize the global application of ctDNA in the prognostic management of solid tumor patients and to evaluate the quality of the current studies.

Methods

PubMed, Web of Science, Embase, Cochrane Library, Scopus, and clinical trials.gov databases were searched to collect cohort studies on ctDNA in the prognosis of solid tumor patients from January 2016 to May 2022. The language was limited to English. Information including general information, participants and cancer characteristics, ctDNA and outcome information were extracted. The quality of the studies was assessed using the Newcastle-Ottawa Scale checklist.

Results

SUBMITTER: Zhang M 

PROVIDER: S-EPMC12010383 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature