Alteration of salivary <i>Streptococcus</i> is associated with statin therapy in older adults: a cohort study.

ABSTRACT:

Background

Salivary microbiome alterations are associated with chronic diseases, such as cardiovascular disease, diabetes, and dementia. These chronic diseases often coexist in older adults, leading to polypharmacy. This situation complicates the relationship between systemic diseases and salivary microbiome dysbiosis. Previous studies have demonstrated the association of the human gut microbiome with common prescription drug use, including polypharmacy. However, a comprehensive analysis of the salivary microbiome and prescription drugs is yet to be conducted in older adults. Therefore, in this study, we performed a multivariate analysis to investigate the relationship between salivary microbiomes and host variables, including prescribed drugs, cognitive function, and oral health,

SUBMITTER: Hisamatsu D 

PROVIDER: S-EPMC12010438 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature