Neutrophil infiltration and microglial shifts in sepsis induced preterm brain injury: pathological insights.

ABSTRACT: Preterm sepsis is a major contributor to brain injury and long-term neurodevelopmental impairments, but its molecular mechanisms remain poorly understood. This study integrated clinical and experimental approaches to investigate the pathological changes linking systemic inflammation to brain injury in preterm infants. Transcriptomic analysis of septic preterm infants' peripheral blood revealed upregulated immune, metabolic, and inflammatory pathways, suggesting a link between systemic and brain inflammation. Using P2 mice, we established a preterm white matter injury model through multiple doses of lipopolysaccharide, observing dose-dependent developmental delays, brain inflammation, and long-term behavioral deficits. Integrative analyses of peripheral blood and brain samples from both mic

SUBMITTER: Zhu J 

PROVIDER: S-EPMC12010587 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature