PTEN as a prognostic factor for radiotherapy plus immunotherapy response in nasopharyngeal carcinoma.

ABSTRACT:

Background

In the context of nasopharyngeal carcinoma (NPC) treatment, radiotherapy combined with immunotherapy (IR + RT) is gaining traction. This study focuses on analyzing exosomal proteins, particularly Phosphatase and Tensin Homolog (PTEN), for predicting the efficacy of NPC treatments. Serum samples from NPC patients and IR + RT recipients were utilized for exosome (Exo) extraction and subsequent transcriptomic and proteomic analyses to identify treatment-related proteins. Flow cytometry of cells and exosomal analysis were performed to examine these proteins. In vitro experiments using C666-1 cells and their Exos explored various cellular responses, while a murine subcutaneous NPC model investigated the impact of PTEN modulation on tumor growth and the immune microenvironment

SUBMITTER: Guo J 

PROVIDER: S-EPMC12010603 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature