Association of serum neurofilament light chain and bone mineral density in adults.

ABSTRACT:

Background

Serum neurofilament light chain (sNFL) is a blood-based marker of neuroaxonal damage increasingly used in neurological research. Although sNFL has been linked to systemic aging and chronic disease, its relationship with bone mineral density (BMD) remains unclear.

Methods

We analyzed data from 1,344 participants aged ≥ 20 years in the 2013-2014 National Health and Nutrition Examination Survey (NHANES). Serum sNFL concentrations were measured using a high-sensitivity immunoassay. Lumbar BMD was assessed by dual-energy X-ray absorptiometry. Multivariable linear regression models were used to evaluate associations between log-transformed sNFL and BMD, adjusting for demographic, lifestyle, metabolic, renal, cognitive, and bone-related covariates. Sensitivity analyses e

SUBMITTER: Lan M 

PROVIDER: S-EPMC12010620 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature