Undenatured type II collagen for knee osteoarthritis.

ABSTRACT:

Introduction

Knee Osteoarthritis (OA) leads to significant pain and reduced function and affects patients' overall quality of life (QoL). Conservative modalities are the first line of management, resorting to surgery only if they fail. However, these modalities have limitations, and do not address the underlying cause of knee OA. The use of nutraceuticals, including native/undenatured type II collagen (UC-2), has evolved and shown promise in the conservative management of knee OA. This article highlights the mechanism of action, and qualitatively presents the pre-clinical, clinical and on-going scientific literature exploring the safety and efficacy of UC-2 for the management of knee OA.

Methods

A search was performed using multiple databases (PubMed, Web of Science, Embase

SUBMITTER: Gupta A 

PROVIDER: S-EPMC12010644 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature