The causal impact of bioavailable testosterone levels on osteoarthritis: a bidirectional Mendelian randomized study.

ABSTRACT:

Background

It has been shown that low testosterone levels are associated with the development of osteoarthritis (OA). In our study, we aimed to investigate a bidirectional causal relationship between bioavailable testosterone levels and OA using Mendelian randomization (MR) analysis.

Methods

In our study, the datasets from publicly available genome-wide association study (GWAS) were adopted, including the OA-related dataset (ukb-b-14486) and the bioavailable testosterone levels-related dataset (ebi-a-GCST90012104). The UKB-B-14,486 dataset contains 462,933 samples in total, including 38,472 OA samples, 424,461 control samples, and 9,851,867 SNPs, all collected from the European population in 2018. Additionally, the EBI-A-GCST90012104 dataset includes 382,988 samples and 16,1

SUBMITTER: Jiang Z 

PROVIDER: S-EPMC12010663 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature