Effects of oral clonidine on bleeding in pelvic and acetabular fractures surgery: a randomized controlled trial.

ABSTRACT:

Background

High blood loss results in major complications in pelvic and acetabular surgeries. Decrement of blood loss during and after surgery reduces morbidity and mortality of the patients. Clonidine is an antihypertensive alpha-2 agonist that has been shown to reduce blood loss in different surgeries. This study aims to evaluate the effects of preoperative oral administration of clonidine in patients who underwent surgery for pelvic and acetabulum fractures.

Methods

A randomized, triple-blinded clinical trial was conducted on 88 patients (79 men and 9 women) scheduled for pelvic or acetabular fracture surgery. Patients were divided into two groups. The intervention group received 200 mcg of oral clonidine 75 to 90 min before anesthesia. Control groups received a placebo w

SUBMITTER: Qoreishy M 

PROVIDER: S-EPMC12010678 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature