Pathogenetic Involvement of Autophagy and Mitophagy in Primary Progressive Multiple Sclerosis.

ABSTRACT: Primary progressive multiple sclerosis (PPMS) affects a subset of MS patients and is characterised by continuous progression from the onset. The molecular mechanisms underlying PPMS are poorly understood, and therapeutic options are limited, with no specific markers for early detection and monitoring. This study investigated the roles of autophagy and mitophagy in PPMS. We found that autophagy markers (ATG5 and ATG7) and mitophagy markers (Parkin and Optineurin) were significantly reduced in the serum of PPMS patients compared to control and relapsing-remitting MS (RRMS) individuals. This reduction was associated with an increase in markers indicative of neurodegeneration and mitochondrial dysfunction. Additionally, a positive correlation between autophagy and mitophagy proteins in the PPM

SUBMITTER: Patergnani S 

PROVIDER: S-EPMC12010764 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature