Characteristics of RET gene mutations in Vietnamese medullary thyroid carcinoma patients: a single-center analysis.

ABSTRACT:

Background

The RET gene point mutation is the main molecular alteration involved in medullary thyroid carcinoma (MTC) tumorigenesis. Previous studies in Vietnam mainly consisted of case reports, with limited data on larger sample sizes. In this study, we investigated RET gene mutations in exons 10, 11, and 16 and analyzed clinicopathological features of a series of Vietnamese MTC patients.

Methods

We collected 33 tissue samples from patients with MTC and analyzed RET mutations using the Sanger sequencing method. The relationship between hotspot RET mutations (exons 10, 11, 16) and clinicopathological features were investigated.

Results

Among the 33 analyzed cases, 17 tumors (52%) harbored RET mutations in exon 10, 11, or 16. A total of 10 distinct genetic alterations

SUBMITTER: Pham VH 

PROVIDER: S-EPMC12010869 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature