The zebrafish ETS transcription factor Fli1b functions upstream of Scl/Tal1 during embryonic hematopoiesis.

ABSTRACT: During embryonic development, vascular endothelial and hematopoietic cells are thought to originate from a common precursor, the hemangioblast. The evolutionarily conserved ETS transcription factor FLI1 has been previously implicated in hemangioblast formation and hematopoietic and vascular development. However, its role in regulating the hemangioblast transition into hematovascular lineages is still incompletely understood. Its zebrafish paralog Fli1b (also known as Fli1rs) functions partially redundantly with the ETS transcription factor Etv2 (also known as Etsrp) during vasculogenesis and angiogenesis. However, its role in embryonic hematopoiesis has not been previously investigated. Here, we show that zebrafish fli1b mutants have a reduced formation of primitive erythrocytes and hemato

SUBMITTER: Laverde V 

PROVIDER: S-EPMC12010910 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature