Estimating the Effects of Hypothetical Ambient PM2.5 Interventions on the Risk of Dementia Using the Parametric g-Formula in the UK Biobank Cohort.

ABSTRACT:

Background

Emerging evidence identifies ambient particulate matter (PM) with an aerodynamic diameter ≤2.5μm (PM2.5) as a modifiable risk factor for dementia, but the potential health benefits gained by enacting regulations that reduce PM2.5 remain unclear.

Objectives

Our aim was to estimate the total effects of hypothetical ambient PM2.5 interventions starting in late life on the risk of dementia in a cohort using the parametric g-formula.

Methods

We used data from 291,495 participants in the UK Biobank cohort who were free of dementia and ≥55 y of age at baseline (2010). We estimated the total effects of hypothetical ambient PM2.5 interventions (achieving annual average standards of 12 μg/m3, 10 μg/m3, and 9 μg/m3) from 2010 to 2019 on the risk of dementia by calcula

SUBMITTER: Lin C 

PROVIDER: S-EPMC12010936 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature