Lung CD4⁺ resident memory T cells use airway secretory cells to stimulate and regulate onset of allergic airway neutrophilic disease.

ABSTRACT: Neutrophilic asthma is a vexing disease, but mechanistic and therapeutic advancements will require better models of allergy-induced airway neutrophilia. Here, we find that periodic ovalbumin (OVA) inhalation in sensitized mice elicits rapid allergic airway inflammation and pathophysiology mimicking neutrophilic asthma. OVA-experienced murine lungs harbor diverse clusters of CD4⁺ resident memory T (T_RM) cells, including unconventional RORγt^negative/low T helper 17 (T_H17) cells. Acute OVA challenge instigates interleukin (IL)-17A secretion from these T_RM cells, driving CXCL5 production from Muc5ac^high airway secretory cells, leading to destructive airway neutrophilia. The T_RM and epithelial cell signals discovered h

SUBMITTER: Ravi VR 

PROVIDER: S-EPMC12011213 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature