Vitamin D for primary dysmenorrhea and endometriosis-related pain - A systematic review of registered RCTs.

ABSTRACT:

Objective

This systematic review investigates the potential role of vitamin D supplement in alleviating pain associated with primary dysmenorrhea or endometriosis by analysing registered randomised controlled trials (RCTs).

Methods

We comprehensively searched the WHO International Clinical Trials Registry Platform to identify registered RCTs that assessed the effects of vitamin D supplement on pain outcomes in people with primary dysmenorrhea or endometriosis. The primary outcomes of interest were pain severity/intensity, pain duration, pain medication usage and pain-related outcome measurements.

Results

Seven registered RCTs were included in this systematic review. These RCTs had diverse doses and treatment durations of vitamin D supplement used as intervention. They

SUBMITTER: Zhou IW 

PROVIDER: S-EPMC12011270 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature