Recombinant antigen-based lateral flow tests for the detection of Strongyloides stercoralis infection.

ABSTRACT:

Background

Strongyloidiasis is a serious public health issue affecting millions of people worldwide particularly in tropical and subtropical regions. The laboratory diagnosis of strongyloidiasis is often serologically based, typically by enzyme linked immunosorbent assays (ELISA). However, the use of these assays at the point of care requires significantly different approaches for serologic measurements. We sought to determine the diagnostic performance of 2 prototype lateral flow tests alongside the Strongy Detect ELISAs (IgG and IgG4) that uses a cocktail of 2 Ss-specific recombinant antigens, Ss-NIE and Ss-IR.

Methods

The diagnostic performance of the Rapid Diagnostic Tests (RDTs) and ELISAs was determined by using stored serum samples from 17 healthy volunteers, 77 indiv

SUBMITTER: Lontuo-Fogang R 

PROVIDER: S-EPMC12011289 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature