Sex-specific risk factors for new-onset heart failure: the PREVEND study at 25 years.

ABSTRACT:

Background and aims

Current estimates for the lifetime risk to develop heart failure with either a reduced (HFrEF) or preserved ejection fraction (HFpEF) and their associated risk factors are derived from two studies from the USA. The sex-specific lifetime risk and population attributable fraction of potentially modifiable risk factors for incident HFpEF and HFrEF are described in a large European community-based cohort with 25 years of follow-up.

Methods

A total of 8558 participants from the PREVEND cohort were studied at baseline from 1997 onwards and followed until 2022 for cases of new-onset HFrEF (ejection fraction < 50%) and HFpEF (ejection fraction ≥ 50%) by assessment of hospital records.

Results

A total of 804 cases of new-onset HF were identified (534 HFrEF

SUBMITTER: van Essen BJ 

PROVIDER: S-EPMC12011521 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature