Cardiorespiratory Stability in Critically Ill Preterm Infants following Dexmedetomidine Initiation.

ABSTRACT: This study aimed to evaluate cardiorespiratory status in preterm infants receiving dexmedetomidine using high-resolution physiologic data.We analyzed preterm infants with continuous heart rate (HR) and oxygen saturation (SpO₂) data for 24 hours preceding and 48 hours following dexmedetomidine initiation. Invasive arterial blood pressure (ABP), when available, was analyzed.In 100 infants with a mean gestational age of 28 weeks and high baseline illness severity, mean HR decreased from 152 to 141 beats per minute while mean SpO₂ increased from 91 to 93% in the 48 hours after dexmedetomidine initiation (p < 0.01). In 57 infants with continuous ABP monitoring, mean ABP increased from 40 to 42 mm Hg (p = 0.01). Vasoactive-inotropic support increased before an

SUBMITTER: Sullivan BA 

PROVIDER: S-EPMC12011533 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature