5hmC-profiles in Puerto Rican Hispanic/Latino men with aggressive prostate cancer.

ABSTRACT:

Introduction

Puerto Rican (PR) Hispanic/Latino (H/L) men are an understudied population that has the highest prostate cancer (PCa) specific mortality among other Hispanic populations. Little information is known about the higher mortality in PR H/L men. It is thought that epigenetic changes in key genes may play a critical role in aggressive tumors.

Methods

We aimed to identify key 5-hydroxymethylcytosine (5hmC) changes in PR H/L men with aggressive PCa. We performed sequencing analysis using the 5hmC-enriched DNA from 22 prostate tumors and 24 adjacent normal FFPE samples.

Results

We identified 808 differentially methylated genes (DMGs) in tumors compared to adjacent normal tissues. These genes suggest key mechanisms, including upregulated signatures of negative Andr

SUBMITTER: Patel MS 

PROVIDER: S-EPMC12011585 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature