The association between serum uric acid and depression among U.S. National Health and Nutrition Examination Survey.

ABSTRACT:

Background

Previous studies have suggested that serum uric acid (UA) may influence depression through oxidative stress pathways, but with inconclusive results. This study aimed to investigate the association between serum UA levels and depression, as well as potential variations across demographic subgroups in the U.S. adult population.

Methods

A cross-sectional analysis of 23,059 participants from NHANES (2013-2018) was conducted. Serum UA levels were classified into quartiles, and depression was measured using the Patient Health Questionnaire-9 (PHQ-9), with a score ≥ 10 indicating depression. Weighted logistic regression models were used to analyze the association between UA levels and depression, adjusting for demographic and clinical covariates. Subgroup analyses were p

SUBMITTER: He H 

PROVIDER: S-EPMC12011595 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature